{"id":2437,"date":"2020-02-26T12:12:03","date_gmt":"2020-02-26T18:12:03","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=2437"},"modified":"2020-02-26T12:12:03","modified_gmt":"2020-02-26T18:12:03","slug":"research-spotlight-hassane-mchaourab-2","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2020\/02\/26\/research-spotlight-hassane-mchaourab-2\/","title":{"rendered":"Research Spotlight: Hassane Mchaourab"},"content":{"rendered":"<figure id=\"attachment_1513\" aria-describedby=\"caption-attachment-1513\" style=\"width: 150px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03.jpg\"><img data-attachment-id=\"1513\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/hassane-mchaourab\/mchaourab_2019-05-03\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03.jpg\" data-orig-size=\"1692,1700\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;8&quot;,&quot;credit&quot;:&quot;Steve Green&quot;,&quot;camera&quot;:&quot;Canon EOS-1D X&quot;,&quot;caption&quot;:&quot;4-24-2019  - Photos of Hassane Mchaourab, PhD (in cool leather jacket), Jonathan Sheehan, PhD, and Brinda Selvaraj, Program in the Molecular Basis of Genetic Diseases in Light Hall (五一茶馆儿 \\\/ Steve Green)&quot;,&quot;created_timestamp&quot;:&quot;1556121846&quot;,&quot;copyright&quot;:&quot;五一茶馆儿 &amp; Medical Center&quot;,&quot;focal_length&quot;:&quot;26&quot;,&quot;iso&quot;:&quot;3200&quot;,&quot;shutter_speed&quot;:&quot;0.01&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"mchaourab_2019-05-03\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;4-24-2019  &#8211; Photos of Hassane Mchaourab, PhD (in cool leather jacket), Jonathan Sheehan, PhD, and Brinda Selvaraj, Program in the Molecular Basis of Genetic Diseases in Light Hall (五一茶馆儿 \/ Steve Green)&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-300x300.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-1019x1024.jpg\" loading=\"lazy\" class=\"wp-image-1513 size-thumbnail\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-150x150.jpg 150w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-300x300.jpg 300w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-768x772.jpg 768w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03-1019x1024.jpg 1019w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/05\/19171504\/mchaourab_2019-05-03.jpg 1692w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><\/a><figcaption id=\"caption-attachment-1513\" class=\"wp-caption-text\">(五一茶馆儿 \/ Steve Green)<\/figcaption><\/figure>\n<p>CSB Researcher <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/hassane-mchaourab\/\" target=\"_blank\" rel=\"noopener\">Hassane Mchaourab<\/a> and his lab <span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">pinpointed the role of an amino acid residue &#8211; a glutamate &#8211; that is essential for proton sensing &amp; drug resistance. Using a proton gradient, PfMATE undergoes a structural change to allow its substrates to enter through the cytoplasm &amp; get released outside the cell. Read the <a href=\"https:\/\/www.pnas.org\/content\/early\/2020\/02\/18\/1917139117\" target=\"_blank\" rel=\"noopener\">PNAS article<\/a>.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CSB Researcher Hassane Mchaourab and his lab pinpointed the role of an amino acid residue &#8211; a glutamate &#8211; that is essential for proton sensing &amp; drug resistance. Using a proton gradient, PfMATE undergoes a structural change to allow its substrates to enter through the cytoplasm &amp; get released outside the cell. Read the PNAS&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/2437"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=2437"}],"version-history":[{"count":3,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/2437\/revisions"}],"predecessor-version":[{"id":2440,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/2437\/revisions\/2440"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=2437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=2437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=2437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}