Zhang, Yuling; Cao, Hui; Yu, Dongran; Feng, Wanqi; Cao, Shougen; Zhou, Yanbing; Lau, Ken S.; Li, Zequn. (2026).听.听Technology in Cancer Research & Treatment, 25.听
TIPE3聽is a protein that helps regulate important cell signaling pathways involved in growth, survival, and communication. Increasing evidence suggests that it plays a significant role in the development and progression of many cancers, making it a potential target for future precision medicine approaches. This review summarizes current research on TIPE3 and its involvement in a wide range of cancers, including lung, breast, pancreatic, colorectal, ovarian, cervical, and gastric cancers, as well as glioblastoma and acute myeloid leukemia. In most cancers, TIPE3 appears to promote tumor growth, spread, resistance to treatment, changes in the immune environment, and other processes that support cancer progression. However, the authors note that TIPE3 may have the opposite effect in certain cancers, such as聽head and neck squamous cell carcinoma, highlighting that its role can vary depending on the type of tumor and its biological context. The review also examines conflicting findings, particularly in colorectal cancer, and discusses possible reasons for these differences, including how TIPE3 is measured, where it is located within cells, and characteristics of the surrounding tumor environment. Finally, the authors outline future strategies for studying and targeting TIPE3, including improved diagnostic methods, advanced molecular profiling, artificial intelligence鈥揳ssisted drug discovery, and combination therapies. Although no TIPE3-targeted treatments are currently available, the evidence suggests that TIPE3 has strong potential as both a biomarker and a therapeutic target in precision oncology.
Figure 1. TIPE3-mediated signaling pathways and localization-dependent functions in cancer